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I believe it needs to be connected to a USB 3.0 port and that USB 2.0 won't give such a low latency.
You will typically get better low-latency performance with Thunderbolt than USB, though more manufacturers are at last cottoning on to this and developing better USB drivers. Anything RME is always good. Zoom's TAC-2 is a nice piece of kit and I'm told their UAC-series USB interfaces have very good driver software too. The new Focusrite Clarett and second-generation Scarletts are also nice, and excellent value.
RME drivers/TotalMix software is excellent.