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Comments
If you use an EQ with a higher quality mode then you wouldn't experience as much degradation with the tone. The trade off for higher quality is usually latency. I recently upgraded from Fab Filter Pro Q to Pro Q2 and the natural phase mode sounds nicer for distorted guitar in the scenario you've mentioned than the standard zero latency mode.
Alternatively try switching the EQ on and off to see if you're making the tone worse. If it is worse try reducing the amount you're killing resonances while listening to the whole mix and find a best compromise.