One Guitar To Rule Them All........

BloodEagle

Les Paul Custom - looks cool, sounds cool, feels cool

Chris_J

My 335

axisus

My homemade Tele-ish guitar. I need no other.

If we were talking something 'off the shelf' it would be a Fender strat, but not a shiny new one.

dazzajl

When I read the question my first thought was, Strat. Specifically my pink MiM beater. 

But seeing how many folks have had the same brilliant idea, I might choose my other great love and have my Duesenburg Caribou. 

JerkMoans

My amended to feck jazzmaster.

particulars available upon request.

https://imgur.com/a/W87Ac

jdgm

Most likely the Dick Knight guitar I got made in 1979.

Obviously......

blobb

My Manson.

JerkMoans

Fine posts all, but I think we need pictures...

meltedbuzzbox

Jazzmaster without doubt

JerkMoans

meltedbuzzbox said:

Jazzmaster without doubt

Amen, brother 

Schnozz

HSH Superstrat.

jdgm

Sorry can't get a pic to work.

mr-mac

Walnut, vibrola, early 60's,    355

lasermonkey

Jazzmaster, because it's perfect for me. The neck, the feel, that  trem, the sounds and the looks.
As I said, perfect.

Boromedic

The Les Paul Standard in my avatar, bought new and always been around. It's been loaned out, played hard, used on every recording I've ever made (even when I was the drummer), and just keeps sounding better. I'm going to commit sacrilege soon and try some PAF style pickups in there. Time will tell if they last.... 

monofin

My R8. I've had it a couple of years and it's always my go to guitar. 

munckee

JerkMoans said:

Fine posts all, but I think we need pictures...

https://i.imgur.com/2tpYtHe.jpg

MIJ 86 57 reissue 

TheBigDipper

If we're talking a specific instrument that means something to us, then this...

https://www.dropbox.com/s/zjistjogua957lm/Strat.jpg?raw=1

The 1973 Strat that I've owned since 1979. It's been part of my life and I love playing it. 

If we're talking about a guitar that is (or was) available to buy, then probably the Brook Tavy I played a couple of years ago when I was looking for something to play finger-style on. Not quite as good a picking guitar as the Taw I actually bought, but a genuine all-rounder that gave me great pleasure to play and I've regretted not having enough dosh for both at the time (although I don't regret buying the Taw at all). 

Fishboy7

Tele... even though I don't own one at the moment 

stimpsonslostson

My Esquire. 
It's neither fancy nor expensive, but it sounds like ME & I'm completely familiar with it.
Esquire https://imgur.com/a/gXdfg

 and as it's a Tele I can be totally confident it will actually last for the rest of my life!